Prinzide is a combination medicine used to treat high blood pressure. Prinzide contains two medicines: lisinopril (an angiotensin-converting enzyme [ACE] inhibitor) and hydrochlorothiazide (a diuretic [water pill]).
Prinzide can cause a rare but serious allergic reaction leading to extreme swelling of your face, lips, tongue, throat, or gut (causing severe abdominal pain). You may have an increased risk of experiencing these symptoms if you have ever had an allergy to angiotensin-converting enzyme (ACE) inhibitor-type medicines or if you are African American. If you experience any of these symptoms, seek emergency medical attention immediately.
Tell your doctor if you experience lightheadedness, especially during the first few days of Prinzide therapy. If you faint, stop taking Prinzide and tell your doctor immediately.
Vomiting, diarrhea, fever, exercise, hot weather, drinking alcohol, excessive perspiration, and dehydration may lead to an excessive fall in your blood pressure. Tell your doctor if you experience any of these. Make sure to drink plenty of fluids when you are taking Prinzide.
Prinzide may decrease your blood neutrophil (type of blood cells that fight infection) levels, especially if you have a collagen vascular disease (such as lupus [disease that affects the immune system]) or kidney disease.
Promptly report any signs of infection (such as sore throat or fever) to your doctor.
Prinzide is not recommended in people with severe kidney problems.
Prinzide can raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
Prinzide may not work as well in African Americans and may increase the risk of side effects. Contact your doctor if your symptoms do not improve or if they become worse.