Pristiq belongs to the class of medications called serotonin-norepinephrine reuptake inhibitors (SNRIs). Pristiq is used to treat major depressive disorder.
Pristiq can increase suicidal thoughts or actions in some children, teenagers, and young adults when the medicine is first started.
Depression and other serious mental illnesses are the most serious causes of suicidal thoughts and actions. People with bipolar disorder, or who have a family history of bipolar disorder (also called manic-depressive illness) are at a greater risk. Contact your doctor immediately if you experience any changes in your mood, behavior, thoughts, or feelings. This is very important when an antidepressant medicine is first started or when the dose is changed.
Pristiq can cause a severe, possibly life-threatening condition called serotonin syndrome (a drug reaction that causes the body to have too much serotonin, a chemical produced by the nerve cells) or neuroleptic malignant syndrome (a life-threatening brain disorder). Contact your doctor immediately if you experience agitation, hallucinations, coma, fast heartbeat, changes in your blood pressure, increased body temperature, lack of coordination, overactive reflexes, nausea, vomiting, or diarrhea.
Pristiq can cause an increase in your blood pressure. Check your blood pressure regularly, especially if you already have high blood pressure.
Do not suddenly stop taking Pristiq without talking to your doctor first, as this can cause serious side effects.
Pristiq can cause mydriasis (prolonged dilation of the pupils of your eye). Notify your doctor if you have a history of glaucoma (high pressure in your eye).
Pristiq can cause low blood sodium levels. Contact your doctor immediately if you experience headache, difficulty concentrating, confusion, weakness, unsteadiness, hallucinations, falls, or seizures.
Pristiq can cause seizures to develop, especially if you have a history of seizures.
Pristiq can increase your risk of bleeding. Do not take Pristiq with aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs) (such as ibuprofen), or blood-thinners (such as warfarin).
Pristiq can increase your cholesterol. Your doctor may measure your cholesterol levels if you will be on long-term treatment with Pristiq.