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Promethazine with codeine (Codeine Phosphate/Promethazine HCl)

Promethazine with codeine is a medicine used to treat cough and upper respiratory symptoms you can have with allergies or a cold. Promethazine is an antihistamine and codeine is a narcotic cough suppressant.

Promethazine with codeine has abuse potential. Mental and physical dependence can occur with the use of promethazine with codeine when it is used improperly. Promethazine with codeine can cause drowsiness and impair mental and/or physical abilities required for hazardous tasks, such as driving a car or operating machinery. Promethazine with codeine can cause serious and possibly life-threatening respiratory depression (decreased rate of breathing) or increase your risk for a seizure. Tell your doctor if you have any breathing problems (such as chronic obstructive pulmonary disease [narrowing of the lungs that makes it hard to breath], sleep apnea [you stop breathing temporarily during sleep]), or a history of seizures. Promethazine with codeine can cause neuroleptic malignant syndrome (a life-threatening brain disorder). Tell your doctor if you experience a fever, stiff muscles, changes in your mental status, fast or irregular heartbeat, changes in your blood pressure, or excessive sweating. Tell your doctor if you experience any uncontrollable muscle movements. Promethazine with codeine can cause lightheadedness or fainting, especially when you stand up from a lying or sitting position.




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